Progesterone side effects

Progesterone is a medication containing micronized Progesterone, a natural form of the hormone Progesterone, commonly used in gender-affirming care for transgender women (assigned male at birth) or individuals with androgen-dependent conditions. It is often prescribed in combination with estrogen therapy to help promote breast development and mimic the hormonal profile of cisgender women. While progesterone therapy can be beneficial for some individuals, it’s important to be aware of potential unwanted/adverse/side effects. Here are some of them:

Side Effect	Description
Breast tenderness and enlargement	Progesterone therapy, including Progesterone, can cause breast tenderness, soreness, and enlargement due to its effects on breast tissue development.
Mood changes	Some individuals may experience mood swings, irritability, or changes in emotional well-being while taking Progesterone therapy.
Fatigue	Fatigue or feelings of lethargy may occur as a side effect of Progesterone therapy.
Headaches	Headaches are a common side effect of progesterone therapy, including Progesterone use. These headaches may range from mild to moderate in severity.
Nausea	Nausea or gastrointestinal discomfort may occur as a side effect of Progesterone therapy, though this is usually mild and transient.
Changes in libido	Some individuals may experience changes in libido (sex drive) while taking Progesterone therapy.
Fluid retention	Progesterone therapy can lead to fluid retention, causing swelling or bloating in the hands, feet, or other parts of the body.
Weight changes	Some individuals may experience changes in body weight or distribution as a side effect of Progesterone therapy.
Skin changes	Progesterone therapy may cause changes in skin texture, including increased softness or oiliness, as well as changes in pigmentation.
Menstrual-like bleeding	Some individuals may experience breakthrough bleeding or spotting while taking Progesterone therapy, particularly if they have not undergone surgical removal of the gonads.
Sleep disturbances	Progesterone therapy may affect sleep patterns in some individuals, leading to insomnia or disrupted sleep.
Rare allergic reactions	Although rare, some individuals may experience allergic reactions to Progesterone, including rash, itching, swelling, or difficulty breathing. Immediate medical attention is necessary if any signs of an allergic reaction occur.