Testosterone is the primary masculinizing hormone used in gender-affirming hormone therapy for transgender and non-binary people seeking masculinization. Health care choices around testosterone depend on medical history, dosing preferences, convenience and cost.
Injectable Testosterone
Injectable testosterone is a widely used and effective method for testosterone delivery. It is typically administered intramuscularly (IM) or subcutaneously (SC).
- Lower medication cost compared with many topical options.
- Flexibility in dosing (weekly or biweekly).
- Many people achieve stable masculinizing effects.
Topical Gels and Creams
Testosterone gels and compounded creams are applied to the skin daily. Brand-name and generic options exist.
- Needle-free, often preferred by people averse to injections.
- Daily dosing can result in relatively stable testosterone levels.
Comparison
| Form | Typical Dosage/Interval | Typical U.S. Cost (Out of Pocket) | Notes |
|---|---|---|---|
| Injectable – Cypionate | Weekly or bi-weekly IM/SC | ~$30 – $150/month (medication) | Generic cost low |
| Injectable – Enanthate | Weekly or bi-weekly IM/SC | ~$40 – $150/month (medication) | Similar to cypionate |
| Topical Gel – Brand (e.g., AndroGel) | Daily | ~$300 – $650/month | Brand pricing high |
| Topical Gel – Generic | Daily | ~$100 – $300/month | Lower cost than brand but still daily supply |
| Compounded Testosterone Cream | Daily | ~$50 – $200/month | Often cheaper |